1. Please make sure your PC meets minimum system requirements.
2. Add Thronebreaker files to the whitelist of your antivirus and firewall.
3. Disable all unneccessary apps before launching the game (especially apps with overlay) such as:
MSI Gaming app
4. Try launching the game in clean boot mode to check if applications running in the background are interfering with the game.
Here is a guide how to perform clean boot: https://support.microsoft.com/en-us/kb/929135/